Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells
JP Garnett, E Hickman, R Burrows, P Hegyi… - Journal of Biological …, 2011 - ASBMB
In most HCO 3−-secreting epithelial tissues, SLC26 Cl−/HCO 3− transporters work in concert
with the cystic fibrosis transmembrane conductance regulator (CFTR) to regulate the
magnitude and composition of the secreted fluid, a process that is vital for normal tissue
function. By contrast, CFTR is regarded as the only exit pathway for HCO 3− in the airways.
Here we show that Cl−/HCO 3− anion exchange makes a major contribution to transcellular
HCO 3− transport in airway serous cells. Real-time measurement of intracellular pH from …
with the cystic fibrosis transmembrane conductance regulator (CFTR) to regulate the
magnitude and composition of the secreted fluid, a process that is vital for normal tissue
function. By contrast, CFTR is regarded as the only exit pathway for HCO 3− in the airways.
Here we show that Cl−/HCO 3− anion exchange makes a major contribution to transcellular
HCO 3− transport in airway serous cells. Real-time measurement of intracellular pH from …
